Contact

sarah.hainer[at]pitt.edu

412-624-6164

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PUBLISHED WORK

2019 - PRESENT

The Hainer Lab opened at the University of Pittsburgh in 2018

DC Klein and SJ Hainer. Chromatin regulation and dynamics in stem cells. Current Topics in Developmental Biology. 2019 

DC Klein and SJ Hainer. Genomic methods in profiling DNA accessibility and factor localization. Chromosome Research. 2019 PDF

SJ Hainer*, A Boskovic, KN McCannell, OJ Rando, and TG Fazzio*. Profiling of Pluripotency Factors in Single Cells and Early Embryos. Cell. 2019 April 2 pii: S0092-8674(19)30276-4. PDF

*indicates co-corresponding authors

C Tavera-Montañez*, SJ Hainer*, D Cangussu, Y Xiao, P Reyes-Gutierrez, Y Yoon, J Rivera- Pérez, AN Imbalzano, JG Navea, TG Fazzio and T Padilla-Benavides. MTF1, a classic metal sensing transcription factor, promotes myogenesis in response to copperFASEB J. 2019 Dec; 33(12):14556-14574 PDF

*indicates co-first authors

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SJ Hainer* and TG Fazzio*. High-Resolution Chromatin Profiling Using CUT&RUN. Current Protocols in Molecular Biology. 2019 Jan 28:e85. PDF

*indicates co-corresponding authors

PRE-2018

Postdoctoral work with Thomas Fazzio 2012-2017 

Graduate work with Joseph Martens 2007-2012

D Acharya, SJ Hainer, Y Yoon, F Wang, I Bach, JA Rivera-Perez, TG Fazzio. KAT-independent gene regulation by Tip60 promotes ESC self-renewal but not pluripotency. Cell Reports. 2017 19: 671-679. PDF

SJ Hainer, KN McCannell, J Yu, L Ee, LJ Zhu, OJ Rando, TG Fazzio. DNA methylation directs genomic localization of Mbd2 and Mbd3 in ES cells. eLIFE. 2016 Nov 16;5. PDF

SJ Hainer and JA Martens. Regulation of chaperone binding and nucleosome dynamics by key residues within the globular domain of histone H3. Epigenetics & Chromatin. 2016 Apr 30;9:17. PDF

SJ Hainer and TG Fazzio. Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome. Cell Reports. 2015 Oct 6;13(1):61-9. PDF

SJ Hainer, W Gu, BR Carone, BL Landry, OJ Rando, CC Mello, TG Fazzio. Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF. Genes & Development. 2015 Feb 15;29(4): 362-378. PDF

PB Chen, LJ Zhu, SJ Hainer, KN McCannell, TG Fazzio. Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo. BMC Genomics. 2014 15:1104. PDF

BR Carone, JH Hung, SJ Hainer, MT Chou, DM Carone, Z Weng, TG Fazzio, OJ Rando. High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm. Developmental Cell. 2014 Jul 14:11-22. PDF

SJ Hainer, BA Charsar, SB Cohen, JA Martens. Identification of mutant versions of the Spt16 histone chaperone that are defective for transcription-coupled nucleosome occupancy in Saccharomyces cerevisiae. G3 (Bethesda). 2012 May 2:555-567. PDF

JA Pruneski, SJ Hainer, KO Petrov, JA Martens. The Paf1 complex represses SER3 transcription in Saccharomyces cerevisiae by facilitating intergenic transcription-dependent nucleosome occupancy of the SER3 promoter. Eukaryotic Cell. 2011 Oct;10(10):1283-94. PDF

SJ Hainer and JA Martens. Identification of histone mutations that are required for transcription-coupled nucleosome occupancy. Molecular and Cellular Biology. 2011 Sep;31(17):3557-68. PDF

SJ Hainer and JA Martens. Transcription of ncDNA across regulatory sequences: many roads lead to local gene regulation. Transcription. 2011 May/June 2(3):120-123. PDF

SJ Hainer, JA Pruneski, RD Mitchell, R Monteverde, JA Martens. Intergenic transcription causes repression by directing nucleosome assembly. Genes & Development. 2011 Jan 1;25(1):29-40. PDF

A PUBMED LIST OF OUR PUBLISHED WORK CAN BE FOUND HERE